Crocin Protects Against Retinal Ischemia-Reperfusion Injury via Regulating Sirt6-Mediated Nrf2/HO-1 Pathway in Rats.

چکیده

To examine if crocin protects retinal ganglion cells (RGCs) from retinal ischemia-reperfusion (RIR) injury by activating the Sirt6-mediated Nrf2/HO-1 signaling pathway. Primary RGCs were isolated and treated with crocin (8-12 µM) under oxygen and glucose deprivation/reperfusion (OGD/R) conditions,…

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