Epigenetic Reprogramming Via Sodium Butyrate Induces Corneal Myofibroblast Dedifferentiation In Vitro and Inhibits Fibrosis In Vivo.

چکیده

Abnormal corneal myofibroblast (CMF) differentiation and persistence in stroma after ocular trauma causes corneal fibrosis and impaired vision. This study tested whether epigenetic reprogramming via sodium butyrate (NaB), histone deacetylase inhibitor, could provoke CMF dedifferentiation into…

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