Generation of a Mouse Model of Fuchs Endothelial Corneal Dystrophy by Knock-in of CTG Trinucleotide Repeat Expansion in the TCF4 Gene.

چکیده

Fuchs endothelial corneal dystrophy (FECD) is frequently associated with trinucleotide repeat (TNR) expansion in the TCF4 gene intron. The aim of this study was to establish a novel FECD mouse model with TNR expansion. We used CRISPR/Cas9-mediated genome editing to generate knock-in mice carrying…

متن کامل چکیده در سایت ناشر در دسترس است.

موضوعات مرتبط

• قرنیه