Investigative ophthalmology & visual science۲۰۲۶نمایه شده در PubMed
Junjie Tang, Zhihui Zhang, Jianjie Lv, Meng Wang, Hetian Sun, Lan Yao, Jinmiao Li, Yaoming Liu, Weifeng Huang, Yang Gao, Yifan Zhu, Shicai Su, Rong Lu
چکیده
Amplification of MYCN is a primary driver of aggressive retinoblastoma (RB), yet it remains a challenging therapeutic target. This study aimed to evaluate the therapeutic potential of the PROTAC molecule HLB-0532259 in degrading MYCN and suppressing RB growth. Y79 and WERI-Rb1 RB cell lines were…
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DOI: 10.1167/iovs.67.10.50